학술논문
3-methyl-4-nitrophenol disturbs the maternal-to-zygotic transition of early embryos by damaging mitochondrial function and histone modification
Document Type
Article
Author
Source
In Ecotoxicology and Environmental Safety 1 January 2025 289
Subject
Language
ISSN
0147-6513
Abstract
@@@@Highlights •PNMC exposure impaired mice blastocyst formation and decreased the quality of preimplantation embryos.•PNMC treatment disturbed the global gene expression of 2-cell embryos.•PNMC exposure disrupted the maternal-to-zygotic transition, alongside the failure of zygotic genome activation and maternal factors degradation.•PNMC treatment damaged the mitochondrial function, inducing oxidative stress and DNA damage.•PNMC exposure broke the level of histone modification.