학술논문
UBE2S facilitates glioblastoma progression through activation of the NF-κB pathway via attenuating K11-linked ubiquitination of AKIP1
Document Type
Article
Author
Han, Zhibin ; Xu, Lin ; Wang, Aowen ; Wang, Baoju ; Liu, Qinfang ; Liu, Hongyang ; Liu, Qi ; Gang, Zhenbo ; Yu, Shengkun ; Mu, Long ; Weng, Changjiang ; Lin, Zhiguo ; Hu, Li
Source
In International Journal of Biological Macromolecules October 2024 278 Part 1
Subject
Language
ISSN
0141-8130
Abstract
Highlights •A novel UBE2S/AKIP1/USP15-NF-κB signaling axis was identified.•UBE2S directly interacts with AKIP1, leading to decreased K11-linked polyubiquitination of AKIP1.•The deubiquitinase USP15 mediates the UBE2S-induced reduction of K11-linked polyubiquitination on AKIP1.•Accumulated UBE2S/AKIP1 complex promotes nuclear translocation of NF-κB.•Silencing UBE2S expression suppresses GBM cell proliferation and tumor growth in vivo.