학술논문
Gestational diabetes mellitus-derived miR-7-19488 targets PIK3R2 mRNA to stimulate the abnormal development and maturation of offspring-islets
Document Type
Article
Author
Xu, Chunxue ; Zou, Linhai ; Wang, Li ; Lv, Wenshan ; Cao, Xiangju ; Jia, Xinyu ; Wang, Yuan ; Jiang, Guohui ; Ji, Lixia
Source
In Life Sciences 15 February 2025 363
Subject
Language
ISSN
0024-3205
Abstract
@@@@Highlights •miR-7-19488 is the key different microRNA in GDM umbilical vein blood-derived exosomes.•miR-7-19488 targets PIK3R2 mRNA to activate PI3K enzyme in fetal islet cells.•The PI3K-Akt signaling stimulates α−/β- cell development and local GLP1-GLP1R axis.•GLP1-GLP1R axis cooperates with miR-7-19488 to promote β-cell functional maturation.