학술논문
Autism Detection in Children by Combined Use of Gaze Preference and the M-CHAT-R in a Resource-Scarce Setting
Document Type
Journal Articles
Reports - Research
Reports - Research
Author
Jensen, Kelly; Noazin, Sassan (ORCID 0000-0002-2043-2615 ); Bitterfeld, Leandra; Carcelen, Andrea; Vargas-Cuentas, Natalia I.; Hidalgo, Daniela; Valenzuela, Alejandra; Roman-Gonzalez, Avid; Krebs, Casey; Clement, Vincent; Nolan, Cody; Barrientos, Franklin; Mendoza, Ardi Knobel; Noriega-Donis, Paola; Palacios, Claudia; Ramirez, Andrea; Vittet, Macarena; Hafeez, Emil; Torres-Viso, Mariana; Velarde, Myriam; Moulton, Lawrence H.; Powers, Michael D.; Gilman, Robert H.; Zimic, Mirko
Source
Subject
Language
English
ISSN
0162-3257
Abstract
Most children with autism spectrum disorder (ASD), in resource-limited settings (RLS), are diagnosed after the age of four. Our work confirmed and extended results of Pierce that eye tracking could discriminate between typically developing (TD) children and those with ASD. We demonstrated the initial 15 s was at least as discriminating as the entire video. We evaluated the GP-MCHAT-R, which combines the first 15 s of manually-coded gaze preference (GP) video with M-CHAT-R results on 73 TD children and 28 children with ASD, 36-99 months of age. The GP-MCHAT-R (AUC = 0.89 (95%CI: 0.82-0.95)), performed significantly better than the MCHAT-R (AUC = 0.78 (95%CI: 0.71-0.85)) and gaze preference (AUC = 0.76 (95%CI: 0.64-0.88)) alone. This tool may enable early screening for ASD in RLS. [This article was written on behalf of the Autism Working Group in Peru: Vanessa Cavallera, Ricardo Zavaleta, Juan Flores, Dennis Nuñez, Alejandro Dioses, and Anna Smith.]