부산대학교 도서관

Background Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) is independently associated with cardiovascular risk, probably via inflammatory activity in sclerotic plaque. We speculated whether Lp-PLA 2 has a role in the aetiology of vascular calcifications, estimated from circulating uncarboxylated matrix Gla protein (MGP) species and whether we could find a potential interaction of Lp-PLA 2 and MGP in terms of mortality. Materials and Methods We examined 798 patients (mean age 65.1 years) with stable vascular disease and followed them in a prospective study. Both, desphospho-uncarboxylated and total MGP (dp-ucMGP or t -ucMGP) were quantified by pre-commercial ELISA assays, developed by VitaK (Maastricht, The Netherland) Results Lp-PLA 2 activity was independently positively associated with desphospho-uncarboxylated MGP (dp-ucMGP) [ β coeff = 0.098, p = 0.006]. 1SD of Lp-PLA 2 activity was associated with 37% increased risk ( p = 0.001) of elevated dp-ucMGP (≥977 pmol/L, top quartile). In the Cox proportional hazard model adjusted for conventional risk factors, the patients in the highest quartile of dp-ucMGP or lowest quintile of total-uncarboxylated ucMGP (<2660 nmol/L) had higher risk of all-cause mortality [HRR 2.79 (95% CI 1.97–3.94) and HRR 1.69 (95% CI 1.18–2.42), respectively]. We observed no effect of high Lp-PLA 2 activity (≥195 nmol/min/mL) on total mortality. Conclusions We assume that Lp-PLA 2 is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA 2 itself. [ABSTRACT FROM AUTHOR]