학술논문
Dynamics of DNA Synthesis Disturbance and Recovery after Fractionated Irradiation of S Phase Cells.
Document Type
Article
Author
Source
Subject
*DNA synthesis
*PHYSIOLOGICAL effects of radiation
*EPITHELIAL cells
*LABORATORY mice
*CORNEA physiology
*CELL physiology
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Language
ISSN
0007-4888
Abstract
Using the autoradiographic method we studied the kinetics of DNA synthesis during themitotic cycle of mouse corneal epithelial cells after γ-irradiation in a dose of 2 Gy at different S-phase points. Normally, S phase in corneal epitheliocytes includes S1 and S2 phases separated by an interval during which DNA is not synthesized. Double exposure modifi es the pattern of DNA synthesis in the cell due to reparation of injuries. The reparative processes in the cell are realized during the interval between the S1 and S2 phases and at the expense of g1 period of the mitotic cycle. If the cell has no time for reparation, the injuries are transferred into the class of 'latent' injuries. [ABSTRACT FROM AUTHOR]