학술논문

Systemic Treatments for Noninfectious Vitreous Inflammation.
Document Type
Article
Source
Mediators of Inflammation. 2013, Vol. 2013, p1-11. 11p.
Subject
*INFLAMMATION
*ETIOLOGY of diseases
*RHEUMATOLOGY
*CALCINEURIN
*ADRENOCORTICAL hormones
*BIOCHEMICAL mechanism of action
*CLINICAL trials
Language
ISSN
0962-9351
Abstract
Vitreous inflammation, or vitritis, may result from many causes, including both infectious and noninfectious, including rheumatologic and autoimmune processes. Vitritis is commonly vision threatening and has serious sequelae. Treatment is frequently challenging, but, today, there are multiple methods of systemic treatment for vitritis. These categories include corticosteroids, antimetabolites, alkylating agents, T-cell inhibitors/calcineurin inhibitors, and biologic agents. These treatment categories were reviewed last year, but, even over the course of just a year, many therapies have made progress, as we have learned more about their indications and efficacy. We discuss here discoveries made over the past year on both existing and new drugs, as well as reviewing mechanisms of action, clinical dosages, specific conditions that are treated, adverse effects, and usual course of treatment for each class of therapy. [ABSTRACT FROM AUTHOR]