학술논문
Decreased CD1a+ , CD83+ and factor XIIIa+ dendritic cells in cervical lymph nodes and palatine tonsils of AIDS patients.
Document Type
Article
Author
Source
Subject
*DENDRITIC cells
*AIDS patients
*CERVIX uteri
*LYMPH nodes
*TONSILS
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*
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Language
ISSN
0309-0167
Abstract
Aims The purpose of this study was to quantify and compare the density of dendritic cells ( DCs) in cervical lymph nodes ( LNs) and palatine tonsils ( PTs) of AIDS and non- AIDS patients. Methods and results Factor XIIIa, CD1a and CD83 antibodies were used to identify migratory DCs by immunohistochemistry in LNs and PTs of 32 AIDS patients and 21 HIV-negative control patients. Quantification was performed by the positive pixel count analytical method. AIDS patients presented a lower density of factor XIIIa+ cells ( P < 0.001), CD1a+ cells ( P < 0.05) and CD83+ cells ( P < 0.001) in cervical LNs and PTs compared to the non- AIDS control group. Conclusion Overall depletion of DCs in lymphoid tissues of AIDS patients may be predictive of the immune system's loss of disease control. [ABSTRACT FROM AUTHOR]