학술논문
The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes.
Document Type
Article
Author
Source
Subject
*GLUTATHIONE transferase
*HAPLOTYPES
*DNA adducts
*LEUCOCYTES
*CIGARETTE smokers
*GENETIC carriers
*POLYCYCLIC aromatic hydrocarbons
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Language
ISSN
1383-5718
Abstract
Highlights: [•] Bulky DNA adduct levels were not different among low-level smokers and non-smokers. [•] GSTM1null volunteers had marginally significant lower adduct levels than GSTM1 ones. [•] MGMT Leu84Phe heterozygotes had a higher level of adducts than homozygous wild type. [•] GSTM1null-MGMT rs12917 haplotype was associated to adduct levels in smokers. [Copyright &y& Elsevier]