학술논문
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Document Type
Article
Source
Subject
*Sirtuins
*Cell-mediated cytotoxicity
*Glial cell line-derived neurotrophic factor
*Lipopolysaccharides
*p53 antioncogene
*Caspases
*Cellular signal transduction
*Apoptosis
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Language
ISSN
0304-3940
Abstract
Highlights: [•] Treatment with LPS caused significant decrease in SIRT1 expression. [•] SIRT1 regulated the releases of IL-6 and TNF-a. [•] SIRT1 played a protective role to circumvent apoptosis. [•] SIRT1-p53-caspase signaling cascade was activated in PD model of inflammation. [ABSTRACT FROM AUTHOR]