학술논문
The rate of spontaneous mutations in human myeloid cells.
Document Type
Article
Author
Source
Subject
*ACUTE myeloid leukemia
*GENETIC mutation
*CELL division
*GLYCOSYLPHOSPHATIDYLINOSITOL
*LYMPHOBLASTOID cell lines
*PAROXYSMAL hemoglobinuria
*LEUKEMIA etiology
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Language
ISSN
0027-5107
Abstract
Highlights: [•] We provide the first measurement of the mutation rate (μ) in human myeloid cells. [•] μ is measured to be 3.6–23×10−7 per cell division. [•] The AML-ETO and MLL-AF9 fusions do not seem to increase μ. [•] Cooperating mutations in NRAS, FLT3 and p53 not seem to increase μ. [•] Hypermutability may be required to explain leukemogenesis. [ABSTRACT FROM AUTHOR]