학술논문
Proteomics analysis of autophagy-deficient Atg7−/− MEFs reveals a close relationship between F-actin and autophagy.
Document Type
Article
Author
Source
Subject
*PROTEOMICS
*AUTOPHAGY
*FIBROBLASTS
*F-actin
*GENETIC regulation
*DEPOLYMERIZATION
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Language
ISSN
0006-291X
Abstract
Highlights: [•] We identified 114 significantly altered proteins in Atg7−/− MEFs. [•] It included 48 up-regulated proteins and 66 down-regulated proteins. [•] F-actin was the center in the down-regulated protein network. [•] F-actin was loose and disassembled in the Atg7−/− MEFs. [•] Depolymerization of F-actin impaired autophagosome maturation in WT MEFs. [ABSTRACT FROM AUTHOR]