학술논문

Seroprevalence and Risk Factors for Cytomegalovirus Infections in Adolescent Females.
Document Type
Article
Source
Journal of the Pediatric Infectious Diseases Society. Mar2013, Vol. 2 Issue 1, p7-14. 8p.
Subject
*SEROPREVALENCE
*CYTOMEGALOVIRUS diseases
*INTELLECTUAL disabilities
*MENTAL health of teenagers
*MULTIVARIATE analysis
*MEDICAL screening
Language
ISSN
2048-7193
Abstract
Background Congenital cytomegalovirus (CMV) is a leading cause of disability, including sensorineural hearing loss, developmental delay, and mental retardation. Understanding risk factors for acquisition of CMV infection in adolescent females will help determine vaccine strategies. Methods Females (12–17 years) were recruited from primary care settings in Cincinnati, Galveston, Houston, and Nashville from June 2006 to July 2010 for a seroepidemiologic study, from which seronegative participants were recruited for a CMV vaccine trial. Participants (n = 1585) responded to questions regarding potential exposures. For those with young children in the home (n = 859), additional questions were asked about feeding and changing diapers, and for those > 14 years of age (n = 1162), questions regarding sexual activity were asked. Serum was evaluated for CMV antibody using a commercial immunoglobulin G assay. Results Cytomegalovirus antibody was detected in 49% of participants. In the univariate analyses, CMV seroprevalence was significantly higher among African Americans, those with children < 3 years of age in the home, and those with a history of oral, anal, or vaginal intercourse. Among those with young children in the home, feeding children and changing diapers further increased the association with CMV infection. However, in the final multivariate analysis, only African Americans and household contact with young children were associated with CMV infection. Conclusions By age 12, evidence of CMV infection was common. Multiple factors regarding race and personal behaviors likely contribute to seroconversion earlier in life. [ABSTRACT FROM AUTHOR]