학술논문
The Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network.
Document Type
Article
Author
Schendel, Diana; DiGuiseppi, Carolyn; Croen, Lisa; Fallin, M.; Reed, Philip; Schieve, Laura; Wiggins, Lisa; Daniels, Julie; Grether, Judith; Levy, Susan; Miller, Lisa; Newschaffer, Craig; Pinto-Martin, Jennifer; Robinson, Cordelia; Windham, Gayle; Alexander, Aimee; Aylsworth, Arthur; Bernal, Pilar; Bonner, Joseph; Blaskey, Lisa
Source
Subject
*AUTISM
*CHILD development deviations
*EPIDEMIOLOGY
*EPIDEMIOLOGICAL research
*EXPERIMENTAL design
*INTERVIEWING
*MEDICAL cooperation
*PARENTS
*QUALITY assurance
*QUESTIONNAIRES
*RESEARCH
*SCALES (Weighing instruments)
*SAMPLE size (Statistics)
*DATA analysis
*CONTENT mining
*CASE-control method
*DESCRIPTIVE statistics
*DISEASE complications
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Language
ISSN
0162-3257
Abstract
The Study to Explore Early Development (SEED), a multisite investigation addressing knowledge gaps in autism phenotype and etiology, aims to: (1) characterize the autism behavioral phenotype and associated developmental, medical, and behavioral conditions and (2) investigate genetic and environmental risks with emphasis on immunologic, hormonal, gastrointestinal, and sociodemographic characteristics. SEED uses a case-control design with population-based ascertainment of children aged 2-5 years with an autism spectrum disorder (ASD) and children in two control groups-one from the general population and one with non-ASD developmental problems. Data from parent-completed questionnaires, interviews, clinical evaluations, biospecimen sampling, and medical record abstraction focus on the prenatal and early postnatal periods. SEED is a valuable resource for testing hypotheses regarding ASD characteristics and causes. [ABSTRACT FROM AUTHOR]