학술논문
Interferon-beta-1b increases serum interleukin-12 p40 levels in primary progressive multiple sclerosis patients
Document Type
Article
Author
Source
Subject
*MULTIPLE sclerosis
*INTERFERONS
*INTERLEUKIN-1
*CYTOKINES
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*
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Language
ISSN
0304-3940
Abstract
Serum levels of interleukin-12 heterodimer (IL-12p70) and its homodimeric subunit (IL-12p40) were analyzed by enzyme-linked immunosorbent assay in 18 patients with primary progressive multiple sclerosis (MS) during 3 months before and 3 months under treatment with interferon-beta-1b (IFNβ-1b, Betaferon™, eight million units (MIU) every other day subcutaneously). Median IL-12p40 levels in MS patients before treatment (66.5 and 63.9 pg/ml) were not elevated compared to 18 healthy controls. IL-12p40 significantly increased during treatment (P<0.0001 , median 105.3 pg/ml after 1 month and 95.3 pg/ml after 3 months). Detectable serum levels of IL-12p70 before therapy were only found in one patient. IL-12p70 did not increase during treatment. These data show that immunological processes may also play a role in primary progressive MS and that IFNβ-1b has an immunomodulating effect in this particular MS subtype. [Copyright &y& Elsevier]