학술논문
Cross Metathesis Assisted Solid-Phase Synthesis of Glycopeptoids.
Document Type
Article
Source
Subject
*METATHESIS reactions
*SOLID-phase synthesis
*GLYCOPEPTIDES
*ALKENES
*PEPTIDOMIMETICS
*CHEMICAL derivatives
*
*
*
*
*
Language
ISSN
1523-7060
Abstract
A solid-phase synthesis of glycopeptoids was explored through olefin cross metathesis (CM). Peptoids and sugar derivatives with appropriate olefin moieties were coupled in the presence of an olefin metathesis catalyst to afford glycopeptoids in good yields. This systematic solid-phase CM study can provide facile access to the molecular sources of glycopeptidomimetics and postchemical modifications on various molecular scaffolds. [ABSTRACT FROM AUTHOR]