부산대학교 도서관

To evaluate the efficacy of Magnesium sulphate and Phenytoin sodium regime in the prevention & control of eclamptic fits. This retrospective study was conducted for one year. 197 eclamptic cases were reported of which 147 cases were managed with magnesium sulphate and 47 were managed with Phenytoin sodium regime.There were 197 cases of eclampsia among 12,170 deliveries, incidence being 1.61%. In magnesium sulphate regime, seizures were controlled within 4hrs of therapy in 97.94% patients while it was 80.86% in Phenytoin sodium group. Recurrent convulsions with Magnesium sulphate (4.76%) were less as compared to phenytoin sodium(34.04%)p<0.01. 91.8% of patients in Magnesium sulphate regained their consciousness within 12 hrs of therapy while it was only 70-72% in Phenytoin sodium regime p<0.01.It is therefore inferred that Magnesium Sulphate therapy has proved superior to Phenytoin sodium regime because of minimal CNS depressant action, minimal fits recurrence and better level of consciousness.All the above factors collectively help in reducing maternal mortality and morbidity &improving foetal salvage. [ABSTRACT FROM AUTHOR]