학술논문
Carnitine Administration Reduces Cytokine Levels, Improves Food Intake, and Ameliorates Body Composition in Tumor-Bearing Rats.
Document Type
Article
Author
Source
Subject
*CARNITINE
*CYTOKINES
*INGESTION
*MAMMAL body composition
*GENE expression
*APPETITE loss
*CACHEXIA
*LABORATORY rats
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Language
ISSN
0735-7907
Abstract
Increased cytokine expression contributes to the pathogenesis of cancer anorexia-cachexia syndrome. Carnitine may reduce inflammation in chronic diseases. We tested the effects of L-propionylcarnitine (PC group) or saline (C group) on food intake (FI), body composition, and inflammatory status of MCA-sarcoma-bearing rats. On tumor appearance, rats were randomly assigned to daily i.p. injection of L-propionylcarnitine (250 mg/kgBW/d; n == 8) or saline (equal volume; n == 8). FI and fat-free mass wasting improved in PC rats only ( p < .01 vs. controls). Cytokines' levels decreased in PC rats vs. controls ( p < .02). Results suggest that carnitine may ameliorate cancer anorexia-cachexia, via reduction of the inflammatory status. [ABSTRACT FROM AUTHOR]