학술논문
Lack of association of FcγRIIIb polymorphisms with systemic lupus erythematosus: a meta-analysis.
Document Type
Article
Author
Source
Subject
*LUPUS erythematosus
*LUPUS nephritis
*GENETIC polymorphisms
*GENE frequency
*META-analysis
*EUROPEANS
*ASIANS
*HEALTH
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Language
ISSN
0172-8172
Abstract
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Fcγ receptor genes have been suggested to play an important role in the pathogenesis of SLE and lupus nephritis (LN). This study aims to assess the association between FcγRIIIb-NA1/NA2 polymorphism and the susceptibility to SLE and lupus nephritis. Relevant studies were identified from electronic databases. A meta-analysis was performed for heterogeneity test and pooled OR calculation. The overall OR of NA2/NA2 homozygous genotype and NA2 allele frequency showed no significant association with SLE and lupus nephritis. Similarly, the association between FcγRIIIb-NA1/NA2 polymorphism and SLE and lupus nephritis was not found in European and Asian population. Taken together, our results suggest that FcγRIIIb might not be a susceptibility gene for SLE and lupus nephritis. [ABSTRACT FROM AUTHOR]