부산대학교 도서관

A series of microPET imaging studies were conducted in anesthetized rhesus monkeys using the dopamine D-selective partial agonist, [F]. There was variable uptake in regions of brain known to express a high density of D receptors under baseline conditions. Pretreatment with lorazepam (1 mg/kg, i.v. 30 min) to reduce endogenous dopamine activity before tracer injection resulted in a dramatic increase in uptake in the caudate, putamen, and thalamus, and an increase in the binding potential (BP) values, a measure of D receptor binding in vivo. These data indicate that there is a high level of competition between [F] and endogenous dopamine for D receptors in vivo. Synapse 2011. © 2011 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]