학술논문

Analgesic use during pregnancy and risk of infant leukaemia: a Children's Oncology Group study.
Document Type
Journal Article
Source
British Journal of Cancer. 2/1/2011, Vol. 104 Issue 3, p532-536. 5p. 2 Charts.
Subject
*ANALGESICS
*BLOOD diseases in pregnancy
*ACUTE myeloid leukemia
*NONSTEROIDAL anti-inflammatory agents
*STATISTICAL significance
*ACETAMINOPHEN
*LOGISTIC regression analysis
*DISEASE risk factors
*ASPIRIN
*CLINICAL trials
*COMPARATIVE studies
*LEUKEMIA
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*RESEARCH funding
*EVALUATION research
*PRENATAL exposure delayed effects
Language
ISSN
0007-0920
Abstract
Background: Infant leukaemia is likely initiated in utero.Methods: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression.Results: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy.Conclusion: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia. [ABSTRACT FROM AUTHOR]