학술논문
The amino acid variation of HLA-A*02:182 in a highly conserved region is predicted to be functionally similar to HLA-A*02:01:01:01 allele.
Document Type
Article
Source
Subject
*AMINO acid sequence
*MAJOR histocompatibility complex
*NUCLEOTIDE sequence
*BONE marrow
*ORGAN donors
*ARGININE
*STEM cell transplantation
*EXONS (Genetics)
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*
*
*
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Language
ISSN
0001-2815
Abstract
We here describe the identification of the novel human leukocyte antigen allele HLA-A*02:182 which has been detected in a potential bone marrow donor. The new allele differs from the sequence of HLA-A*02:01:01:01 only by a non-synonymous nucleotide exchange of Guanin (G) → Cytosin (C) at position 199 in exon 3 replacing amino acid (AA) Arginine (Arg, R) by Threonine (Thr, T) in codon 157. Since the HLA-A*02:01:01:01 allele differs from A*02:182 only at AA position 157, it is assumed that the protein structures of these alleles are highly similar. A mismatch between HLA-A*02:01:01:01 and HLA-A*02:182 is predicted to have a very low allogeneic potential in hematopoietic stem cell transplantation. [ABSTRACT FROM AUTHOR]