학술논문
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Document Type
Article
Author
Thye1,2, Thorsten; Vannberg, Fredrik O.; Wong, Sunny H.; Owusu-Dabo, Ellis; Osei6, Ivy; Gyapong, John; Sirugo, Giorgio; Sisay-Joof, Fatou; Enimil, Anthony; Chinbuah, Margaret A.; Floyd, Sian; Warndorff, David K.; Sichali, Lifted; Malema, Simon; Crampin, Amelia C.; Ngwira, Bagrey; Teo, Yik Y.; Small, Kerrin; Rockett, Kirk; Kwiatkowski, Dominic
Source
Subject
*DISEASE susceptibility
*TUBERCULOSIS
*LINKAGE disequilibrium
*CHROMOSOMES
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Language
ISSN
1061-4036
Abstract
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 × 10−9, odds ratio = 1.19, 95% CI = 1.13–1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low. [ABSTRACT FROM AUTHOR]