학술논문
Anti-tuberculosis activity and drug interaction with nevirapine of inhalable lipid microspheres containing rifampicin in murine model.
Document Type
Article
Source
Subject
*RIFAMPIN
*DRUG side effects
*DRUG interactions
*LUNG disease treatment
*MICROSPHERES
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Language
ISSN
0265-2048
Abstract
Intranasal administration of lipid microspheres (LM) containing rifampicin (LM-RFP) exhibited the bacteriostatic effect against Mycobacterium tuberculosis H37Rv. The efficacies of intranasal LM-RFP in lung were markedly higher in immunodeficient BALB/c nude mice ( p < 0.001), but not different in immunocompetent BALB/c mice ( p = 1.000) compared to the results of oral rifampicin groups. When intranasal LM-RFP was given instead of oral rifampicin, the reductions of Cmax and AUC0–3 of nevirapine were decreased from 32.2% to 11.9% and 30.5% to 12.4%, respectively. These results suggested that intranasal LM-RFP could improve the anti-tuberculosis activity in immunodeficient host and minimize drug interaction between rifampicin and nevirapine. [ABSTRACT FROM AUTHOR]