부산대학교 도서관

Objective:Common variants near melanocortin receptor 4 (MC4R) have been related to fatness and type 2 diabetes. We examined the associations of rs17782313 and rs17700633 in relation to body fat, body fat distribution, metabolic traits, weight development and energy expenditure.Methods:Obese young men (n=753, BMI31.0 kg m−2) and a randomly selected group (n=874) identified from a population of 174 800 men were re-examined in three surveys at mean ages 35, 46 and 49 years (S-35, S-46 and S-49). Measurements were available at upto eight times from birth to adulthood. Logistic regression analysis was used to assess odds ratio (OR) for the presence of the carrier allele for a given difference in phenotypic values.Results:Rs17782313 minor C-allele was associated with overall, abdominal and peripheral fatness (range of OR=1.06–1.14 per z-score units) at all three surveys, although only consistently significant at S-35 and S-46. Rs17700633 minor A-allele was also associated with the fatness measures, but significantly so only at S-49 for overall and abdominal fatness (range of OR=1.03–1.15 per z-score units), and peripheral fatness (OR=1.15–1.20 per z-score units). There were only few significant associations with metabolic traits. The rs17782313 C-allele and the rs17700633 A-allele were both associated with lower high-density lipoprotein cholesterol (range of OR=0.64–0.84 per mol l−1), significantly at S-46. The rs17700633 A-allele was significantly associated with insulin (OR=1.25 per 50 pmol l−1), leptin (OR=1.42 per 10 ng μl−1) and insulin sensitivity (OR=0.81 per model unit). The rs17782313 C-allele and the rs17700633 A-allele were both associated with BMI in childhood and adolescence (range of OR=1.04–1.17 per z-score units), significant for the rs17782313 C-allele at the age of 13–19 years and for rs17700633 A-allele at age 7, 10, 13 and 19 years. No significant associations were found for energy expenditure.Conclusion:Near MC4R variants appear to contribute to body fat, body fat distribution, some metabolic traits, weight development during childhood, but not to energy expenditure. [ABSTRACT FROM AUTHOR]