부산대학교 도서관

Abstract. The measurement of regional cerebral bloodflow (rCBF) and perfusion reserve (PR) with H[sub 2][sup 15]O positron emission tomography (PET) and acetazolamide challenge is of importance in evaluating patients with cerebrovascular disease and is thought to be useful inselecting patients for possible vascular surgery. Full quantitative assessment of rCBF with PET requires arterial blood sampling, which is inconvenient in a clinical setting. In this work, we present a simple non-invasive method with which to quantitatively evaluate PR in one PET session lasting no more than 30 min. In ten patientswith cerebrovascular disease, rCBF was measured withH[sub 2][sup 15]O PET under the baseline condition and after administrationof 1 g acetazolamide using a standard techniqueinvolving arterial blood sampling. The activity accumulatedover 60 s was normalized to injected activity perkilogram body weight (naa) and compared with rCBFin eight different brain regions. A high linear correlation was found for PR based on naa (PR[sub nAA]) and rCBF(PR[sub rcBF]) (PR[sub nAA]=0.843 PR[sub rcBF] + 0.092, r=0.83, Pearson's correlation coefficient). Bland-Altman analyses furtherconfirmed that PR, AA reflects PR in a quantitative manner. These results demonstrate that the method based on normalized counts allows the quantitative assessment of PR without blood sampling. [ABSTRACT FROM AUTHOR]