학술논문
Conservative Treatment of the Uremic Syndrome.
Document Type
Article
Author
Vanholder, Raymond; Argilés, Angel; Beige, Joachim; Brunet, Philippe; Drüeke, Tilman B.; Fliser, Danilo; Herget-Rosenthal, Stefan; Hörl, Walter H.; Jörres, Achim; Perna, Alessandra; Rodriguez-Portillo, Mariano; Spasovski, Goce; Stegmayr, Bernd; Stenvinkel, Peter; Wanner, Christoph; Wiecek, Andrzej; Massy, Ziad A.
Source
Subject
*THERAPEUTICS
*HEMOLYTIC-uremic syndrome
*RENAL biopsy
*KIDNEY diseases
*CARDIOVASCULAR diseases
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Language
ISSN
0894-0959
Abstract
In addition to extracorporeal renal replacement strategies, which in chronic kidney disease (CKD) are largely reserved for the treatment of end-stage kidney failure, conservative measures can be taken to reduce concentration, effects, or both concentration and effects of uremic retention solutes. In this overview, we will focus on those therapies, which are aimed at preventing or delaying cardio-vascular disease, retarding or halting the progression of CKD, or both. We will discuss, consecutively, inhibitors of the renin–angiotensin–aldosterone axis, beta-blockers, calcium-channel antagonists, anti-inflammatory drugs, intestinal sorbents, calcimimetics, and glitazones. Some of these approaches could lead to a therapeutic breakthrough in the future. In addition, comprehensive tables will be provided for more traditional therapeutic approaches, such as lifestyle changes and other pharmaceutical treatments. [ABSTRACT FROM AUTHOR]