학술논문
Synthesis and Antiviral Evaluation of 2'-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-d]Pyrimidine Ribonucleosides.
Document Type
Article
Author
Source
Subject
*PYRIMIDINE nucleotides
*RIBONUCLEASES
*URIDINE
*NUCLEOSIDES
*NUCLEOTIDES
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*
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*
Language
ISSN
1525-7770
Abstract
A series of novel 2'-C-methylribonucleosides, involving 5-iodo and 5-alkynyl uridine analogues as well as related bicyclic furano- and pyrrolo[2,3-d]pyrimidinone compounds, has been synthesized and evaluated for their inhibitory effect on replication of the hepatitis C virus (HCV). The new nucleoside analogues did not show meaningful anti-HCV activity. [ABSTRACT FROM AUTHOR]