학술논문
Whole Genome Sequence Dataset of Mycobacterium tuberculosis Strains from Patients of Campania Region.
Document Type
Academic Journal
Author
Folliero V; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.; Ferravante C; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Baronissi, SA, Italy.; Molecular Pathology and Medical Genomics Program, San Giovanni di Dio e Ruggi D'Aragona University Hospital, Salerno, Italy.; Iovane V; Department of Agricultural Sciences, University of Naples Federico II, Portici, Naples, Italy.; Salvati A; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Baronissi, SA, Italy.; Molecular Pathology and Medical Genomics Program, San Giovanni di Dio e Ruggi D'Aragona University Hospital, Salerno, Italy.; Crescenzo L; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Baronissi, SA, Italy.; Perna R; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.; Laboratory of Microbiology and Virology, Ospedali dei Colli, Naples, Italy.; Corvino G; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.; UOC Microbiology - Ospedale Cardinale Ascalesi, ASL NA1, Naples, Italy.; Della Rocca MT; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.; UOSD Microbiology - AORN Sant 'Anna and San Sebastiano, Caserta, Italy.; Panetta V; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.; UOSD Microbiology - AORN Sant 'Anna and San Sebastiano, Caserta, Italy.; Tranfa A; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.; UOC Microbiology and Virology- San Giuseppe Moscati Hospital, Avellino, Italy.; Greco G; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.; Clinical Pathology and Microbiology Unit, San Giovanni di Dio e Ruggi D'Aragona University Hospital, Salerno, Italy.; Baldoni T; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.; Laboratory of Microbiology and Virology, Ospedali dei Colli, Naples, Italy.; Pagnini U; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.; Finamore E; UOC Virology and Microbiology - University Hospital AOU 'Luigi Vanvitelli', Naples, Italy.; Giurato G; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Baronissi, SA, Italy.; Nassa G; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Baronissi, SA, Italy.; Coppola M; Laboratory of Microbiology and Virology, Ospedali dei Colli, Naples, Italy.; Atripaldi L; Laboratory of Microbiology and Virology, Ospedali dei Colli, Naples, Italy.; Greco R; UOSD Microbiology - AORN Sant 'Anna and San Sebastiano, Caserta, Italy.; D'Argenio A; UOC Microbiology and Virology- San Giuseppe Moscati Hospital, Avellino, Italy.; Foti MG; UOC Microbiology and Virology- San Giuseppe Moscati Hospital, Avellino, Italy.; Abate R; UOC Microbiology - Ospedale Cardinale Ascalesi, ASL NA1, Naples, Italy.; Del Giudice A; Laboratory of Microbiology and Virology, Ospedali dei Colli, Naples, Italy.; Sarnelli B; UOC Microbiology - Ospedale Cardinale Ascalesi, ASL NA1, Naples, Italy.; Weisz A; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Baronissi, SA, Italy.; Molecular Pathology and Medical Genomics Program, San Giovanni di Dio e Ruggi D'Aragona University Hospital, Salerno, Italy.; Iovane G; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.; Pinto R; UOD Prevenzione e Sanità Pubblica Veterinaria, Direzione Generale Tutela della Salute - Regione Campania, Naples, Italy.; Franci G; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Baronissi, SA, Italy. gfranci@unisa.it.; Clinical Pathology and Microbiology Unit, San Giovanni di Dio e Ruggi D'Aragona University Hospital, Salerno, Italy. gfranci@unisa.it.; Galdiero M; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy. massimiliano.galdiero@unicampania.it.; UOC Virology and Microbiology - University Hospital AOU 'Luigi Vanvitelli', Naples, Italy. massimiliano.galdiero@unicampania.it.
Source
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101640192 Publication Model: Electronic Cited Medium: Internet ISSN: 2052-4463 (Electronic) Linking ISSN: 20524463 NLM ISO Abbreviation: Sci Data Subsets: MEDLINE
Subject
Language
English
Abstract
Tuberculosis (TB) is one of the deadliest infectious disorders in the world. To effectively TB manage, an essential step is to gain insight into the lineage of Mycobacterium tuberculosis (MTB) and the distribution of drug resistance. Although the Campania region is declared a cluster area for the infection, to contribute to the effort to understand TB evolution and transmission, still poorly known, we have generated a dataset of 159 genomes of MTB strains, from Campania region collected during 2018-2021, obtained from the analysis of whole genome sequence. The results show that the most frequent MTB lineage is the 4 according for 129 strains (81.11%). Regarding drug resistance, 139 strains (87.4%) were classified as multi susceptible, while the remaining 20 (12.58%) showed drug resistance. Among the drug-resistance strains, 8 were isoniazid-resistant MTB, 4 multidrug-resistant MTB, while only one was classified as pre-extensively drug-resistant MTB. This dataset expands the existing available knowledge on drug resistance and evolution of MTB, contributing to further TB-related genomics studies to improve the management of this disease.
(© 2024. The Author(s).)
(© 2024. The Author(s).)