학술논문

Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative.
Document Type
Academic Journal
Author
Sanchez E; L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Wilkinson T; L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Coughlan G; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Mirza S; L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Baril AA; Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.; Ramirez J; Dr. Sandra Black Centre for Brain Resilience & Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Binns MA; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Black SE; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Dr. Sandra Black Centre for Brain Resilience & Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Borrie M; Lawson Health Research Institute, London, Ontario, Canada.; Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Dilliott AA; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.; Dixon RA; Department of Psychology, Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.; Dowlatshahi D; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Farhan S; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.; Finger E; Lawson Health Research Institute, London, Ontario, Canada.; Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Fischer CE; Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Frank A; Bruyere Research Institute, University of Ottawa, Ottawa, Ontario, Canada.; Freedman M; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.; Department of Medicine, Mt. Sinai Hospital, Toronto, Ontario, Canada.; Goncalves RA; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.; Grimes DA; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Brain and Mind Research Institute, Ottawa, Ontario, Canada.; Hassan A; Thunder Bay Regional Research Institute, Northern Ontario School of Medicine, Thunder Bay, Ontario, Canada.; Hegele RA; Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Robarts Research Institute, Western University, London, Ontario, Canada.; Kumar S; Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Lang AE; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada.; Marras C; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada.; McLaughlin PM; Nova Scotia Health, Halifax, Nova Scotia, Canada.; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.; Orange JB; School of Communication Sciences and Disorders, Western University, London, Ontario, Canada.; Canadian Centre for Activity and Aging, Western University, London, Ontario, Canada.; Pasternak SH; Department of Clinical Neurological Sciences, Robarts Research Institute, Western University, London, Ontario, Canada.; Parkwood Institute, St. Joseph's Health Care Centre, Western University, London, Ontario, Canada.; Pollock BG; Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.; Rajji TK; Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Roberts AC; School of Communication Sciences and Disorders, Western University, London, Ontario, Canada.; Canadian Centre for Activity and Aging, Western University, London, Ontario, Canada.; Robinson JF; Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Robarts Research Institute, Western University, London, Ontario, Canada.; Rogaeva E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Sahlas DJ; McMaster University, Hamilton, Ontario, Canada.; Saposnik G; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Stroke Outcomes and Decision Neuroscience Unit, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Strong MJ; Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Canadian Institutes for Health Research, Ottawa, Ontario, Canada.; Swartz RH; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Tang-Wai DF; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Krembil Brain Institute Memory Clinic, University Health Network, Toronto, Ontario, Canada.; Tartaglia MC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Krembil Brain Institute Memory Clinic, University Health Network, Toronto, Ontario, Canada.; Troyer AK; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.; Neuropsychology and Cognitive Health, Baycrest Health Sciences, Toronto, Ontario, Canada.; Kvartsberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Dementia Research Institute, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin, Madison, Wisconsin, USA.; Munoz DP; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.; Masellis M; L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Source
Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: We investigated whether novel plasma biomarkers are associated with cognition, cognitive decline, and functional independence in activities of daily living across and within neurodegenerative diseases.
Methods: Glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau (p-tau)181 and amyloid beta (Aβ) 42/40 were measured using ultra-sensitive Simoa immunoassays in 44 healthy controls and 480 participants diagnosed with Alzheimer's disease/mild cognitive impairment (AD/MCI), Parkinson's disease (PD), frontotemporal dementia (FTD) spectrum disorders, or cerebrovascular disease (CVD).
Results: GFAP, NfL, and/or p-tau181 were elevated among all diseases compared to controls, and were broadly associated with worse baseline cognitive performance, greater cognitive decline, and/or lower functional independence. While GFAP, NfL, and p-tau181 were highly predictive across diseases, p-tau181 was more specific to the AD/MCI cohort. Sparse associations were found in the FTD and CVD cohorts and for Aβ 42/40 .
Discussion: GFAP, NfL, and p-tau181 are valuable predictors of cognition and function across common neurodegenerative diseases, and may be useful in specialized clinics and clinical trials.
(© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)