학술논문

Candidate diagnostic biomarkers for neurodevelopmental disorders in children and adolescents: a systematic review.
Document Type
Academic Journal
Author
Cortese S; Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.; Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK.; Solent NHS Trust, Southampton, UK.; Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York, NY, USA.; Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, UK.; Solmi M; Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.; Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada.; Department of Mental Health, Ottawa Hospital, Ottawa, ON, Canada.; Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program, University of Ottawa, Ottawa, ON, Canada.; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.; Michelini G; Department of Biological & Experimental Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles (UCLA), Los Angeles, CA, USA.; Bellato A; School of Psychology, University of Nottingham, Semenyih, Malaysia.; Blanner C; Mental Health Center, Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.; Canozzi A; Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.; Eudave L; Faculty of Education and Psychology, University of Navarra, Pamplona, Spain.; Farhat LC; Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.; Højlund M; Department of Psychiatry Aabenraa, Mental Health Services in the Region of Southern Denmark, Aabenraa, Denmark.; Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Köhler-Forsberg O; Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Leffa DT; ADHD Outpatient Program & Development Psychiatry Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Rohde C; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Affective Disorders, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.; de Pablo GS; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Child and Adolescent Mental Health Services, South London and Maudsley NHS Foundation Trust, London, UK.; Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Institute of Psychiatry and Mental Health, Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, CIBERSAM, Madrid, Spain.; Vita G; Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.; Wesselhoeft R; Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Child and Adolescent Mental Health Odense, Mental Health Services in the Region of Southern Denmark, Odense, Denmark.; Martin J; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; Baumeister S; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.; Bozhilova NS; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; School of Psychology, University of Surrey, Guilford, UK.; Carlisi CO; Division of Psychology and Language Sciences, University College London, London, UK.; Leno VC; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Floris DL; Department of Psychology, University of Zurich, Zurich, Switzerland.; Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands.; Holz NE; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.; Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands.; Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.; Kraaijenvanger EJ; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.; Sacu S; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.; Vainieri I; Department of Clinical, Educational and Health Psychology, University College London, London, UK.; Ostuzzi G; Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.; Barbui C; Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.; Correll CU; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.; Psychiatry Research, Northwell Health, Zucker Hillside Hospital, New York, NY, USA.; Department of Psychiatry and Molecular Medicine, Zucker School of Medicine, Hempstead, NY, USA.; Center for Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA.
Source
Publisher: Masson Italy Country of Publication: Italy NLM ID: 101189643 Publication Model: Print Cited Medium: Print ISSN: 1723-8617 (Print) Linking ISSN: 17238617 NLM ISO Abbreviation: World Psychiatry Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
1723-8617
Abstract
Neurodevelopmental disorders - including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, communication disorders, intellectual disability, motor disorders, specific learning disorders, and tic disorders - manifest themselves early in development. Valid, reliable and broadly usable biomarkers supporting a timely diagnosis of these disorders would be highly relevant from a clinical and public health standpoint. We conducted the first systematic review of studies on candidate diagnostic biomarkers for these disorders in children and adolescents. We searched Medline and Embase + Embase Classic with terms relating to biomarkers until April 6, 2022, and conducted additional targeted searches for genome-wide association studies (GWAS) and neuroimaging or neurophysiological studies carried out by international consortia. We considered a candidate biomarker as promising if it was reported in at least two independent studies providing evidence of sensitivity and specificity of at least 80%. After screening 10,625 references, we retained 780 studies (374 biochemical, 203 neuroimaging, 133 neurophysiological and 65 neuropsychological studies, and five GWAS), including a total of approximately 120,000 cases and 176,000 controls. While the majority of the studies focused simply on associations, we could not find any biomarker for which there was evidence - from two or more studies from independent research groups, with results going into the same direction - of specificity and sensitivity of at least 80%. Other important metrics to assess the validity of a candidate biomarker, such as positive predictive value and negative predictive value, were infrequently reported. Limitations of the currently available studies include mostly small sample size, heterogeneous approaches and candidate biomarker targets, undue focus on single instead of joint biomarker signatures, and incomplete accounting for potential confounding factors. Future multivariable and multi-level approaches may be best suited to find valid candidate biomarkers, which will then need to be validated in external, independent samples and then, importantly, tested in terms of feasibility and cost-effectiveness, before they can be implemented in daily clinical practice.
(© 2023 World Psychiatric Association.)