학술논문
Lung cancer susceptibility locus at 5p15.33.
Document Type
Article
Author
McKay, James D.; Hung, Rayjean J.; Gaborieau, Valerie; Boffetta, Paolo; Chabrier, Amelie; Byrnes, Graham; Zaridze, David; Mukeria, Anush; Szeszenia-Dabrowska, Neonilia; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Mates, Dana; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; McLaughlin, John; Shepherd, Frances; Montpetit, Alexandre; Narod, Steven
Source
Subject
*LUNG cancer
*DISEASE susceptibility
*GENOMES
*DNA replication
*BIOMARKERS
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Language
ISSN
1061-4036
Abstract
We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 × 10−7 and P = 4 × 10−6) and replicated by the independent study series (P = 7 × 10−5 and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology. [ABSTRACT FROM AUTHOR]