학술논문
Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population.
Document Type
Article
Author
Source
Subject
*CORONARY disease
*NUCLEOTIDES
*GENETIC polymorphisms
*POPULATION genetics
*CHROMOSOMES
*
*
*
*
Language
ISSN
0278-0240
Abstract
Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ⩽55yr, females ⩽60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 × 10^{-6}, 2.7 × 10^{-6}, 3.8 × 10^{-7}, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p = 7.9 × 10^{-7}). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD. [ABSTRACT FROM AUTHOR]