부산대학교 도서관

Presents a study to establish the biochemical mechanism of Fringe protein action. Evidence that Fringe-dependent elongation of O-linked fucose on Notch receptors modulates Notch signalling by using co-culture assays in mammalian cells and by expression of an enzymatically inactive Fringe mutant in Drosophila; How the modification is an example of the modulation of a signalling event by differential receptor glycosylation and identifies a mechanism that could be relevant to other signalling pathways.