부산대학교 도서관

Objectives: The aim of this study is to evaluate the incidence and types of thyroid dysfunctions induced by amiodarone (AMD) therapy. In the same time we tried to perform some considerations regarding the concrete treatment of AMD-induced abnormalities and the follow up of cases. Material and methods: The study group comprised 85 patients, treated with AMD, issued from an iodine-replete area. The patients with thyroid dysfunctions were evaluated clinically, by means of conventional thyroid sonography, color flow Doppler sonography - CFDS (in selected cases), determinations of plasma levels of TSH, thyroid hormones and antithyroid auto antibodies (AT Abs) Results: 60.9 % of patients remained euthyroid during AMD treatment, hypothyroidism occurred in 15.6% of cases and thyrotoxicosis was diagnosed in 23.5% of subjects Conclusions: AMD may induce different thyroid dysfunctions, with various seventies (sub clinical or clinical forms). Among euthyroid patients, there are some with thyroid morphological and immunological abnormalities, considered "risk cases "for possible future thyroid dysfunctions. All AMD-treated cases should be screened for thyroid dysfunctions before the drug introduction and carefully monitored during the treatment. [ABSTRACT FROM AUTHOR]