학술논문
Multiple ADH genes are associated with upper aerodigestive cancers.
Document Type
Article
Author
Hashibe, Mia; McKay, James D.; Curado, Maria Paula; Oliveira, Jose Carlos; Koifman, Sergio; Koifman, Rosalina; Zaridze, David; Shangina, Oxana; Wünsch-Filho, Victor; Eluf-Neto, Jose; Levi, Jose Eduardo; Matos, Elena; Lagiou, Pagona; Lagiou, Areti; Benhamou, Simone; Bouchardy, Christine; Szeszenia-Dabrowska, Neonilia; Menezes, Ana; Dall'Agnol, Marinel Mór; Merletti, Franco
Source
Subject
*HUMAN genetics
*ALCOHOL dehydrogenase
*ENZYMES
*ETIOLOGY of diseases
*CANCER
*GENES
*
*
*
*
*
Language
ISSN
1061-4036
Abstract
Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10−10 and 10−9, respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology. [ABSTRACT FROM AUTHOR]