학술논문
Quantification of breast tissue density: Correlation between single-sided portable NMR and micro-CT measurements.
Document Type
Academic Journal
Author
Huang X; Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; Translational Research Institute, Woolloongabba, Australia; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Australia.; Ali TS; Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), Brisbane, Australia.; Nano T; Greenslopes Private Hospital, Greenslopes, Australia.; Blick T; Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; Translational Research Institute, Woolloongabba, Australia.; Tse BW; Preclincal Imaging Facility, Translational Research Institute, Woolloongabba, Australia.; Sokolowski K; Preclincal Imaging Facility, Translational Research Institute, Woolloongabba, Australia.; Tourell MC; Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), Brisbane, Australia.; Lloyd T; Radiology Department, Princess Alexandra Hospital, Woolloongabba, Australia.; Thompson EW; Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; Translational Research Institute, Woolloongabba, Australia; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Australia; University of Melbourne, Department of Surgery, St. Vincent's Hospital, Melbourne, Australia.; Momot KI; Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), Brisbane, Australia.; Hugo HJ; Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; Translational Research Institute, Woolloongabba, Australia; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Australia. Electronic address: honor.hugo@qut.edu.au.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214883 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5894 (Electronic) Linking ISSN: 0730725X NLM ISO Abbreviation: Magn Reson Imaging Subsets: MEDLINE
Subject
Language
English
Abstract
Mammographic density (MD) is a strong independent risk factor for breast cancer. Traditional screening for MD using X-ray mammography involves ionising radiation, which is not suitable for young women, those with previous radiation exposure, or those having undergone a partial mastectomy. Therefore, alternative approaches for MD screening that do not involve ionising radiation will be important as the clinical use of MD increases, and as more frequent MD testing becomes desirable for research purposes. We have previously demonstrated the potential utility of spin relaxation-based, single-sided portable-NMR measurements for the purpose of MD quantification. We present here a more refined analysis by quantifying breast tissue density in excised samples on a continuous scale (0% to 100% fibroglandular tissue content) using micro-CT (μCT), and comparing the results to spin-relaxation and diffusion portable-NMR measurements of the same samples. μCT analysis of mammary tissues containing high- and low-MD (HMD and LMD, respectively) regions had Hounsfield Unit (HU) histograms with a bimodal pattern, with HMD regions exhibiting significantly higher HU values than LMD regions. Quantitative MD (%HMD) values obtained using μCT exhibited an excellent correlation with portable-NMR results, namely longitudinal spin-relaxation time constants (T 1 ) and the relative tissue water content obtained from portable-NMR diffusion measurements (R 2 = 0.92, p < 0.0001 and R 2 = 0.96, p < 0.0001, respectively). These findings are consistent with our previous results demonstrating relatively high water content in HMD breast tissue, consistent with the high proportion of fibroglandular tissue, FGT, which in turn contains more abundant water-carrying HSPG proteins. We observed an excellent correlation between the T 1 values and diffusion NMR-measured relative tissue water content (R 2 = 0.94, p < 0.0001). These findings demonstrate, for the first time, the ability of single-sided portable NMR to accurately quantify MD in vitro on a continuous scale. The results also indicate that portable-NMR analysis can assist in the identification of features underpinning MD, namely FGT and adipose tissue content. Future work will involve application of portable NMR to quantifying MD in vivo.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
(Copyright © 2019 Elsevier Inc. All rights reserved.)