학술논문
New Analogs of Acyclovir Substituted at the Side Chain.
Document Type
Article
Author
Source
Subject
*ACYCLOVIR
*PHENYL compounds
*CHEMICAL reactions
*NUCLEOSIDES
*ANTIVIRAL agents
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*
*
*
Language
ISSN
1525-7770
Abstract
A series of novel analogs of acyclovir, substituted with an alkyl (methyl, ethyl, n-butyl) or phenyl group at the positions 1', 4', and/or 5', has been obtained in a direct one-pot coupling reaction of guanosine and the respective 1,3-dioxolanes. The new acyclonucleosides were essentially inactive in antiviral (HSV, VV, VSV, HBV) evaluation in vitro. [ABSTRACT FROM AUTHOR]