부산대학교 도서관

Several studies have described a role for type I interferons (IFNαβ) in the initiation and/or prolongation of autoimmune diseases. Most pronounced has been the association of disease activity with what is now known as ‘the interferon signature’ of gene expression in peripheral blood mononuclear cells from lupus patients. In correlation, studies have shown that inhibition of IFNαβ signaling abrogates disease in various mouse models of lupus. New Zealand black (NZB) and B6.Nba2 congenic mice spontaneously develop elevated levels of serum anti-nuclear autoantibodies (ANAs). Nevertheless, neither of these strains develop fatal renal disease. The female F1 offspring of NZB or B6.Nba2 crossed with New Zealand white (NZW) mice do, however, develop kidney disease. We have previously shown that increases in endogenous IFNαβ levels in (B6.Nba2 × NZW)F1 mice leads to accelerated development of renal disease in an IFNαβ-dependent manner. We now show that B6.Nba2 and (B6.Nba2 × NZW)F1 mice deficient for the IFNαβ-receptor fail to develop ANA and renal disease, although the mice have substantial immune complex deposition in the glomeruli. Thus, endogenous IFNαβ might influence disease by affecting B-cell activation and differentiation, as well as the kidneys’ susceptibility to damage, the latter perhaps through induction of a local inflammatory milieu.Genes and Immunity (2007) 8, 653–662; doi:10.1038/sj.gene.6364430; published online 20 September 2007 [ABSTRACT FROM AUTHOR]