학술논문
Efficient synthesis of 1-azakenpaullone, a selective inhibitor of glycogen synthase kinase-3β for cellular regeneration.
Document Type
Article
Author
Source
Subject
*GLYCOGEN
*GLYCOGEN synthase kinase-3
*REGENERATIVE medicine
*RING formation (Chemistry)
*INDIUM oxide
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Language
ISSN
1144-0546
Abstract
1-Azakenpaullone, a selective inhibitor of glycogen synthase kinase-3β, was synthesized by carrying out a two-step protocol featuring an indium-trichloride-mediated intramolecular cyclization and mild reaction conditions. The concise synthesis showed significantly improved synthetic efficiency and reduced discharge of waste. We expect the present study to boost the applications of 1-azakenpaullone and its analogues in cellular regeneration and regenerative medicine. [ABSTRACT FROM AUTHOR]