부산대학교 도서관

This document provides guidance for researchers studying the long-term safety of topical corticosteroids (TCS). It suggests strategies to minimize confounding factors, such as comparing TCS with active comparators and considering the severity of the underlying skin condition. The document also recommends adjusting for potential confounders like age, sex, and medical comorbidities. It emphasizes the importance of using validated outcome definitions and suggests capturing outcomes not captured in routine health data through prospective registries. The document acknowledges the limited evidence base for the long-term safety of TCS and urges researchers to approach the topic thoughtfully. [Extracted from the article]