부산대학교 도서관

Background: The risk of respiratory syncytial virus (RSV) hospitalization is highest during the first months of life, but few studies have assessed the population‐based rates of hospitalization in monthly age groups of infants. Methods: We determined the average population‐based rates of hospitalization with virologically confirmed RSV infections in children ≤15 years of age admitted during the 10‐year period of 2008–2018. Testing for RSV was routine in all children hospitalized with respiratory infections, and all RSV‐positive children admitted at any time during the study period were included in the analyses. Results: The annual population‐based rate of RSV hospitalization was highest in infants 1 month of age (52.0 per 1000 children; 95% CI, 45.2–59.7), followed by infants <1 month of age (34.8 per 1000; 95% CI, 29.2–41.1) and those 2 months of age (32.2 per 1000; 95% CI, 26.9–38.4). In cumulative age groups, the rate of hospitalization was 39.7 per 1000 (95% CI, 36.2–43.4) among infants <3 months of age, 26.8 per 1000 (95% CI, 24.8–29.0) in infants aged <6 months, and 15.8 per 1000 (95% CI, 14.7–17.0) in those <12 months of age. Conclusion: In monthly age groups of infants, the incidence rates of virologically confirmed RSV hospitalization in all infants up to 3 months of age were substantially higher than those reported in earlier studies. These data may be important for improving the estimates of the cost‐effectiveness of various interventions to reduce the burden of RSV in young infants. [ABSTRACT FROM AUTHOR]