부산대학교 도서관

Simple Summary: This study investigated the transmission of COVID-19 from humans to animals, specifically highlighting a case where a veterinarian contracted the virus from an infected cat. The objectives included examining the presence of SARS-CoV-2 antibodies in Thai cats during various episodes of the outbreak, evaluating the effectiveness of a modified human commercial test kit for screening SARS-CoV-2 antibodies in cats, and investigating the correlation between cat infections and human epidemic episodes. Utilizing 1107 cat serum samples, the results demonstrated a seropositive rate of 22.67%, aligning with trends observed in humans. The cPass™ neutralization test revealed a validated 3.99% seropositivity rate. While distinct patterns were observed among epidemic waves, overall variation was revealed across provinces. Particularly, Samut Sakhon demonstrated a robust positive correlation between the proportion of positive cat sera and human prevalence. This study underscores the importance of continuous surveillance to comprehend the dynamics of SARS-CoV-2 transmission in human and feline populations. Human-to-animal SARS-CoV-2 transmission was observed, including a veterinarian contracting COVID-19 through close contact with an infected cat, suggesting an atypical zoonotic transmission. This study investigated the prevalence of SARS-CoV-2 antibodies in cats during human outbreaks and elucidated the correlation between cat infections and human epidemics. A total of 1107 cat serum samples were collected and screened for SARS-CoV-2 antibodies using a modified indirect ELISA human SARS-CoV-2 antibody detection kit. The samples were confirmed using a cPass™ neutralization test. The SARS-CoV-2 seropositivity rate was 22.67% (199/878), mirroring the trend observed in concomitant human case numbers. The waves of the epidemic and the provinces did not significantly impact ELISA-positive cats. Notably, Chon Buri exhibited a strong positive correlation (r = 0.99, p = 0.009) between positive cat sera and reported human case numbers. Additionally, the cPass™ neutralization test revealed a 3.99% (35/878) seropositivity rate. There were significant differences in numbers and proportions of positive cat sera between epidemic waves. In Samut Sakhon, a positive correlation (r = 1, p = 0.042) was noted between the proportion of positive cat sera and human prevalence. The findings emphasize the need for ongoing surveillance to comprehend SARS-CoV-2 dynamics in both human and feline populations. [ABSTRACT FROM AUTHOR]