부산대학교 도서관

Objectives: Regarding the relationship between donor kidney quality and renal graft function after deceased kidney transplantation (KTx) following donation after cardiac death (DCD), the evaluation timing varies depending on the study. Evaluation of histology and changes in long‐term renal graft function is limited. Methods: A retrospective single‐center study included 71 recipients who underwent 0‐hour biopsy for KTx from DCD. The recipients were divided into two groups to evaluate factors related to renal graft function (study1). The two groups were categorized as stable graft function and poor graft function with the change of estimated glomerular filtration rate (eGFR) after KTx. The recipients were then divided into four groups to assess whether the factors identified in study1 were related to the change in long‐term renal graft function (study2). They were categorized as follows: Improved, Stable, Deteriorated, and Primary non‐function with the change of eGFR after KTx. Results: In study1, donor age ≥ 50 years (29.5% vs. 65.2%; p = 0.09), banff arteriolar hyalinosis (ah) score (0.66 ± 0.78 vs. 1.2 ± 1.0; p = 0.018), and presence of glomerulosclerosis (43.2% vs. 76.2%; p = 0.017) were significant risk factors for poor long‐term graft function. When the recipients were divided into four groups, the severity of ah correlated well with changes in long‐term renal function. Conclusions: We can predict the shift in long‐term renal graft function after KTx from DCD according to the severity of ah by 0‐hour biopsy. [ABSTRACT FROM AUTHOR]