부산대학교 도서관

Background: The predictors and association of new-onset atrial arrhythmias with mortality in hospital-admitted COVID-19 patients were not adequately studied in the past. Objectives and Methods: This was a retrospective cohort study in which the electrocardiogram and telemetry monitoring of 305 consecutively admitted COVID-19 patients were analyzed. The main objectives of the study were to determine the predictors and the association of atrial arrhythmias with in-hospital mortality among hospital-admitted COVID-19 patients. Results: The incidence of atrial arrhythmias was 6.5% (20/305), with atrial fibrillation in 4.9% (15/305), followed by atrial tachycardia in 1.0% (3/305), and multifocal atrial tachycardia in 0.32% (1/305), and atrial flutter in 0.32% (1/305). The cardiac biomarkers, N-terminalpro-BNP (NT-ProBNP) (89.5% vs. 60%, P = 0.012), and troponin I (31.6% vs. 11.3%, P = 0.009) were significantly elevated in patients with atrial arrhythmias. The multivariate binary logistic regression analysis showed acute kidney injury (odds ratio (OR): 5.170, 95% confidence interval (CI): 1.380-19.36, P = 0.015), serum potassium (meq/dL) (OR: 0.318, 95% CI: 0.136-0.740, P = 0.008), intensive care unit (OR: 8.141, 95% CI: 1.816-36.50, P = 0.006), and elevated NT-ProBNP (OR: 9.945, 95% CI: 1.177-84.01, P = 0.035) as the predictors of new-onset atrial arrhythmias. The mortality was significantly associated with atrial arrhythmias in univariate analysis (hazard ratio (HR):3.225 (95% confidence interval (CI): 1.682--6.181; P = 0.002). However, in multivariate cox-regression analysis, no association was found between new-onset atrial arrhythmias and in-hospital mortality (adjusted HR: 1.674 (95% CI: 0.670-4.182); P = 0.270). Conclusions: This study shows atrial arrhythmias as a marker of terminal illness in COVID-19 patients. Multivariate analysis did not show any association between atrial arrhythmias and in-hospital mortality among the hospitalized COVID-19 patients in this study. [ABSTRACT FROM AUTHOR]