학술논문
Retinal Thinning in Adults with Autism Spectrum Disorder.
Document Type
Article
Author
Source
Subject
*RETINAL disease diagnosis
*RETINAL anatomy
*STATISTICS
*REGRESSION analysis
*CASE-control method
*FISHER exact test
*MANN Whitney U Test
*SEVERITY of illness index
*PSYCHOLOGICAL tests
*OPTICAL coherence tomography
*AUTISM
*QUESTIONNAIRES
*DESCRIPTIVE statistics
*MENTAL depression
*DATA analysis software
*STATISTICAL models
*DATA analysis
*COMORBIDITY
*INTELLIGENCE tests
*SYMPTOMS
*ADULTS
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Language
ISSN
0162-3257
Abstract
Since the retina shares its embryological origin with the central nervous system, optical coherence tomography (OCT), an imaging technique frequently employed in ophthalmology to analyze the macula and intraretinal layer thicknesses and volumes, has recently become increasingly important in psychiatric research. We examined 34 autistic and 31 neurotypical adults (NT) using OCT. Autistic adults had reduced overall macular and outer nuclear layer (ONL) thickness and volume compared to NT. Both macular and ONL thickness showed significant inverse associations with the severity of autistic symptoms measured with the Social Responsiveness Scale 2 (SRS-2). Longitudinal studies across different age groups are required to clarify whether retinal changes may represent a possible trait marker. [ABSTRACT FROM AUTHOR]