학술논문
Expansion of Neisseria meningitidis Serogroup C Clonal Complex 10217 during Meningitis Outbreak, Burkina Faso, 2019.
Document Type
Article
Author
Kekeisen-Chen, Joann F.; Tarbangdo, Felix T.; Sharma, Shalabh; Marasini, Daya; Marjuki, Henju; Kibler, Janelle L.; Reese, Heather E.; Ouattara, Seydou; Ake, Flavien H.; Yameogo, Issaka; Ouedraogo, Issa; Seini, Emmanuel; Zoma, Robert L.; Tonde, Issa; Sanou, Mahamoudou; Novak, Ryan T.; McNamara, Lucy A.
Source
Subject
*NEISSERIA meningitidis
*WHOLE genome sequencing
*MENINGITIS
*CEREBROSPINAL fluid
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Language
ISSN
1080-6040
Abstract
During January 28-May 5, 2019, a meningitis outbreak caused by Neisseria meningitidis serogroup C (NmC) occurred in Burkina Faso. Demographic and laboratory data for meningitis cases were collected through national case-based surveillance. Cerebrospinal fluid was collected and tested by culture and real-time PCR. Among 301 suspected cases reported in 6 districts, N. meningitidis was the primary pathogen detected; 103 cases were serogroup C and 13 were serogroup X. Whole-genome sequencing revealed that 18 cerebrospinal fluid specimens tested positive for NmC sequence type (ST) 10217 within clonal complex 10217, an ST responsible for large epidemics in Niger and Nigeria. Expansion of NmC ST10217 into Burkina Faso, continued NmC outbreaks in the meningitis belt of Africa since 2019, and ongoing circulation of N. meningitidis serogroup X in the region underscore the urgent need to use multivalent conjugate vaccines in regional mass vaccination campaigns to reduce further spread of those serogroups. [ABSTRACT FROM AUTHOR]