부산대학교 도서관

Background: We examined the impact of the Clonorchis sinensis (C. sinensis) infection on the survival outcomes of spontaneous rupture Hepatocellular Carcinoma (srHCC) patients undergoing hepatectomy. Methods: Between May 2013 and December 2021, 157 consecutive srHCC patients who underwent hepatectomy were divided into an no C. sinensis group (n = 126) and C. sinensis group (n = 31). To adjust for differences in preoperative characteristics an inverse probability of treatment weighting (IPTW) analysis was done, using propensity scores. Overall survival (OS) and recurrence-free survival (RFS) were compared before and after IPTW. Multivariate Cox regression analysis was performed to determine whether the C. sinensis infection was an independent prognostic factor after IPTW. Results: In original cohort, the no C. sinensis group did not show a survival advantage over the C. sinensis group. After IPTW adjustment, the median OS for the C. sinensis group was 9 months, compared to 29 months for the no C. sinensis group. C. sinensis group have worse OS than no C. sinensis group (p = 0.024), while it did not differ in RFS(p = 0.065). The multivariate Cox regression analysis showed that C. sinensis infection and lower age were associated with worse OS. Conclusions: The C. sinensis infection has an adverse impact on os in srHCC patients who underwent hepatectomy. Author summary: Clonorchis sinensis, a trematode of the Opisthorchiidae family, is a genus of zoonotic parasite and liver fluke. This species specifically resides in the bile ducts of humans and mammals during its adult stage. Known as a class I carcinogen by the International Agency for Research on Cancer, Clonorchis sinensis has gained recognition for its association with cholangiocarcinoma. The occurrence of Clonorchis sinensis and its transmission to humans heavily relies on geographical factors and the dietary preferences of its hosts. Individuals, along with other definitive hosts, contract the parasite by consuming raw or undercooked freshwater fish or shrimp that harbor infective metacercariae. A study indicated that patients with hepatocellular carcinoma combined with Clonorchis sinensis infection have a worse prognosis after hepatectomy. This study aimed to determine the prognostic significance of Clonorchis sinensis infection with spontaneous rupture Hepatocellular Carcinoma(srHCC). We have retrospectively analyzed the infection rate of srHCC. We found that 19.7% of patients with srHCC had a combination of Clonorchis sinensis infection. We also found that srHCC patients with Clonorchis sinensis infection have a worse prognosis after hepatectomy. This is a single center study, hopefully lending guidance the prognosis of srHCC with Clonorchis sinensis. [ABSTRACT FROM AUTHOR]