학술논문
Characterization of Cancer Stem Cells in Olfactory Neuroblastoma Identifies Increased PD-L1 Expression.
Document Type
Article
Author
Source
Subject
*CANCER stem cells
*OLFACTORY receptors
*PROGRAMMED death-ligand 1
*NEUROBLASTOMA
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Language
ISSN
2193-6331
Abstract
This article discusses the characterization of cancer stem cells (CSCs) in olfactory neuroblastoma (ONB), a rare malignant neoplasm. The study aimed to identify the density of CSCs and PD-L1 expression in ONB using immunofluorescence. The results showed that CSCs were present in ONB, but they were uncommon and did not correlate with grade, stage, or recurrence. However, a significant number of CSCs expressed PD-L1, suggesting a potential immunotherapy strategy for ONB by targeting this cell population through PD-1/PD-L1 immune checkpoint blockade. [Extracted from the article]