학술논문
Dynamics of overdose and non-overdose mortality among people living with HIV amidst the illicit drug toxicity crisis in British Columbia.
Document Type
Article
Author
Source
Subject
*HIV-positive persons
*CAUSES of death
*STATISTICS
*CHRONIC pain
*NARCOTIC antagonists
*SUBSTANCE abuse
*CONFIDENCE intervals
*DRUG overdose
*SYNDEMICS
*AGE distribution
*HEPATITIS C
*MANN Whitney U Test
*FISHER exact test
*T-test (Statistics)
*SEX distribution
*DESCRIPTIVE statistics
*HOSPITAL care
*CHI-squared test
*RESEARCH funding
*DRUGS of abuse
*DATA analysis software
*DRUG toxicity
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Language
ISSN
0954-0121
Abstract
We sought to characterize overdose and non-overdose mortality among PLWH amidst the illicit drug toxicity crisis in British Columbia, Canada. A population-based analysis of PLWH (age ≥19) in British Columbia accessing healthcare from April 1996 to March 2017 was conducted using data from the Seek and Treat for Optimal Prevention of HIV/AIDS (STOP HIV/AIDS) cohort linkage. Underlying causes of deaths were stratified into overdose and non-overdose causes. We compared (bivariate analysis) health-related characteristics and prescription history between PLWH died of overdose and non-overdose causes between April 2009 and March 2017. Among 9,180 PLWH, we observed 962 deaths (142 [14.7%] overdoses; 820 [85.2%] other causes). Compared to those who died from other causes, those who died of overdose were significantly younger (median age [Q, Q3]: 46 years [42, 52] vs. 54 years [48, 63]); had an indication of chronic pain (35.9% vs. 27.1%) and hepatitis C virus (64.8% vs. 50.4%), but fewer experienced hospitalization in the year before death. PLWH who died were most likely to be prescribed with opioids (>50%) and least likely with opioid agonist therapy (<10%) in a year before death. These findings highlight the syndemic of substance use, HCV, and chronic pain, and how the crisis is unqiuely impacting females and younger people. [ABSTRACT FROM AUTHOR]